GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs983392 | 1 | rs10897009 | chr11:59923194 | MS4A4A | chr11:60048139-60076444:+ | -0.09 | -3.66 | 0.000269 | Alzheimer's disease (late onset) |
| BRCA | cis | rs2077224 | 1 | rs10897274 | chr11:62200369 | C11orf10 | chr11:61556603-61560085:- | 0.1 | 3.44 | 0.000599 | Chronic obstructive pulmonary disease-related biomarkers |
| BRCA | cis | rs1116547 | 1 | rs10900685 | chr5:112707306 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.09 | 4.68E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs10901513 | 1 | rs10901513 | chr10:127699936 | UROS | chr10:127477148-127511837:- | -0.17 | -4.92 | 9.87E-7 | Visceral fat |
| BRCA | cis | rs10901513 | 1 | rs10901514 | chr10:127700066 | UROS | chr10:127477148-127511837:- | -0.17 | -4.92 | 9.87E-7 | Visceral fat |
| BRCA | cis | rs10901513 | 1 | rs10901520 | chr10:127718837 | UROS | chr10:127477148-127511837:- | -0.17 | -4.8 | 1.84E-6 | Visceral fat |
| BRCA | cis | rs7104764 | 1 | rs10902112 | chr11:244106 | PSMD13 | chr11:236808-252984:+ | -0.16 | -4.58 | 5.13E-6 | Menarche (age at onset) |
| BRCA | cis | rs7104764 | 1 | rs10902113 | chr11:245523 | PSMD13 | chr11:236808-252984:+ | -0.15 | -4.24 | 2.46E-5 | Menarche (age at onset) |
| BRCA | cis | rs7104764 | 1 | rs10902114 | chr11:246234 | PSMD13 | chr11:236808-252984:+ | -0.15 | -4.18 | 3.15E-5 | Menarche (age at onset) |
| BRCA | cis | rs6598955 | 1 | rs10902728 | chr1:26598281 | TRIM63 | chr1:26377798-26394121:- | -0.15 | -4.32 | 1.7E-5 | Obesity-related traits |
| BRCA | cis | rs6598955 | 1 | rs10902728 | chr1:26598281 | ZNF593 | chr1:26496388-26497362:+ | 0.12 | 5.15 | 3.16E-7 | Obesity-related traits |
| BRCA | cis | rs7069346 | 1 | rs10902853 | chr10:124740621 | PSTK | chr10:124739556-124749906:+ | 0.13 | 3.66 | 0.00026 | Migraine without aura |
| BRCA | cis | rs11799420 | 1 | rs10903 | chr1:171673236 | VAMP4 | chr1:171669298-171711214:- | 0.19 | 5.28 | 1.6E-7 | Hippocampal atrophy |
| BRCA | cis | rs8030379 | 1 | rs10906982 | chr15:84568158 | GOLGA6L5 | chr15:85047738-85060078:- | -0.13 | -4.36 | 1.41E-5 | Waist circumference adjusted for body mass index;Waist circumference |
| BRCA | cis | rs9253 | 1 | rs10908353 | chr1:37954950 | SNIP1 | chr1:38002145-38019903:- | -0.19 | -3.78 | 0.000164 | Hemostatic factors and hematological phenotypes |